What should I do if my skin or eyes come in contact with Mitosol?
First aid measures listed in MSDS
Eyes: Remove any contact lenses. Immediately flush eyes with water for 15 minutes keeping eyelids open. Cold water may be used. Do not use an eye ointment. Seek medical help
Skin: Gently wash thoroughly the contaminated skin with water and non-abrasive soap. Cold water may be used. Cover the irritated skin with an emollient. If irritation persists, seek medical attention. If the chemical gets on your clothing, remove the contaminated clothing carefully, using personal protective equipment, and wash areas of body. Wash clothing before reusing. For serious skin contact: Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate medical attention.
Inhalation: Remove to fresh air, seek immediate medical attention. For serious inhalation: Remove to fresh air. Loosen clothing. If having difficulty breathing, administer oxygen. Giving mouth-to-mouth resuscitation may be dangerous. Seek immediate medical attention.
Ingestion: Have conscious person drink several glasses of water or milk. INDUCE VOMITING by sticking finger in throat or give Ipecac if ingestion has been less than 30 minutes. If greater than 30 minutes or unknown, activated charcoal may be administered if victim is alert and conscious (15-30g children; 50-100g adults). Seek immediate medical attention.
Accidental Injection: Seek prompt medical attention.
How do I handle a spill?
On the sterile field- Place a disposable towel or small stack of 4x4s onto the spill and allow it to be absorbed, then place in yellow chemotherapy disposal bag. Gloves must be changed after cleaning a spill. Place used gloves in yellow bag.
Off the sterile field- Don gloves. Place disposable towel onto the spill and allow it to be absorbed, then wipe area of spill with a bleach wipe. Place towel and bleach wipe into yellow chemotherapy disposal bag. Remove gloves and place in yellow bag. Wash hands.
Does the contraindication for pregnancy include pregnant health care workers who work with Mitosol?
Unfortunately, safe use during pregnancy has not been established. The following is a statement from the American Academy of Ophthalmology regarding use of MMC in pregnant/lactating patients.
“Mitomycin C is an antifibrotic agent which is frequently applied in glaucoma surgery. A decrease of mean litter size and body weight and an increase of exencephaly in second gestation mice were associated with mitomycin use.29 There are no studies reporting the teratogenic effect of this drug in the human fetus, though the mechanism of action of the drug strongly suggests a possible teratogenic risk.” -EyeWiki
Although this addresses use in pregnant patients, the issue is exposure to the drug. The Mitosol kit is designed to make the use of MMC in the operating room as safe as possible, however, there is always a potential for exposure, either by contact or inhalation. Therefore, we recommend that pregnant or nursing health care workers avoid working with it if possible. Due to the lack of information on chemotherapy and pregnant healthcare workers, our advice is it’s better to be safe than sorry.
Do I need to wear special gloves when handling Mitosol?
Natural rubber latex, Neoprene and Nitrile gloves display the highest resistance to permeation by Mitosol.